反应详情

温度

200 °C

A mixture of 0.17 g of Compound 5A, 0.13 g of 1-[2-(2,2,2-trifluoroethoxy)phenyl]-piperazine (prepared as described by EP 0748 800, G. Bantle et al.) and 0.07 g of potassium carbonate was heated at 200° C. for 20 minutes. After cooling to 20-25° C., the crude residue was purified by flash chromatography in ethyl acetate/methanol gradient (95:5 to 9:1) to yield 0.193 g (70%) of the title compound. M.p. 152-158° C.

1. temperatureAfter cooling to 20-25° C.
2. customthe crude residue was purified by flash chromatography in ethyl acetate/methanol gradient (95:5 to 9:1)