HCID 15922637, compound → HCID 18398663, compound

HRID 1018960Notes

Reaction equation

HRID 1018960 reaction equation
[N:1]1([CH:10]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([P:21](=[O:32])([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])([F:20])[F:19])=[CH:14][CH:13]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1.[Li]CCCC.[CH:44]([O:47][C:48]1[CH:60]=[C:59]([C:61]2[CH:66]=[CH:65][C:64]([CH2:67]Br)=[CH:63][CH:62]=2)[CH:58]=[CH:57][C:49]=1[C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])([CH3:46])[CH3:45]>CCCCCC.C1COCC1>[N:1]1([C:10]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]([P:21]([O:27][C:28]([CH3:31])([CH3:29])[CH3:30])([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:32])([F:19])[F:20])=[CH:16][CH:17]=2)[CH2:67][C:64]2[CH:63]=[CH:62][C:61]([C:59]3[CH:58]=[CH:57][C:49]([C:50]([O:52][C:53]([CH3:54])([CH3:56])[CH3:55])=[O:51])=[C:48]([O:47][CH:44]([CH3:46])[CH3:45])[CH:60]=3)=[CH:66][CH:65]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1

Participants

6

Reactant 3

HCID 15922637HCID 15922637, compoundHCID 18398661HCID 18398661, compoundHCID 178418339Butyllithium

Product 1

HCID 18398663HCID 18398663, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8058HexaneSolvent

Procedure

To a solution of di(tert-butyl) {4-[2-(1H-1,2,3-benzotriazol-1-yl)-2-phenylethyl]phenyl}(difluoro)methylphosphonate (0.060 g, 0.110 mmol) in TRF (1.0 mL) were added n-BuLi 1.6 M in hexane (0.086 mL) and the bromide of Example 11, Step 1 (0.045 g, 0.111 mmol) in THF (1.0 mL). Then using the same protocol as described for Example 14 Step 1 the title compound was obtained.

Sources & evidence

ORD record
ord-6d6f52b29e674a94bad9bb419d925887
Source dataset
uspto-grants-2002_11
Patent number
US06486141B2

Reaction notes

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