4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine → 4-(4-Piperidinyl)furo[3,2-c]pyridine

HRID 1018988Notes

Reaction equation

HRID 1018988 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:5][CH2:6][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1

Participants

3

Reactant 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

Product 1

HCID 183997754-(4-Piperidinyl)furo[3,2-c]pyridine

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

Workup

  1. temperaturecooled
  2. washwashed with ether
  3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
  4. extractionAfter extraction with dichloromethane
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customto be obtained

Sources & evidence

ORD record
ord-1a40daa6276a4ceb915aa63c280c7240
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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