反应详情

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

1. temperaturecooled
2. washwashed with ether
3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
4. extractionAfter extraction with dichloromethane
5. customthe organic phase is dried
6. filtrationfiltered
7. customevaporated to dryness
8. customto be obtained