Sodium Hydroxide → HCID 22458206, compound

HRID 1018991Notes

Reaction equation

HRID 1018991 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH:16][CH2:17][CH2:18][C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)Cl.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:23]3[CH:22]=[CH:21][S:20][C:19]=3[CH2:18][CH2:17][N:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 18399772HCID 18399772, compound

Product 1

HCID 22458206HCID 22458206, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 2 g of the product obtained in Step C in 8 ml of toluene, and 12 mmol of POCl3, are heated at reflux. After 4 hours, the reaction mixture is poured onto ice, rendered basic by the addition of a 20% sodium hydroxide solution and then extracted with dichloromethane. The organic phase is dried and filtered and then evaporated, enabling the expected product to be isolated.

Workup

  1. temperatureat reflux
  2. additionthe reaction mixture is poured onto ice
  3. extractionextracted with dichloromethane
  4. customThe organic phase is dried
  5. filtrationfiltered
  6. customevaporated
  7. customto be isolated

Sources & evidence

ORD record
ord-b714469f88bb42b8be317953c4795181
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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