Piperazine → HCID 18399724, compound

HRID 1018999Notes

Reaction equation

HRID 1018999 reaction equation
[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12](Br)[C:11]=2[CH:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>C(O)C>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:11]=2[CH:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 18399758HCID 18399758, compound

Product 1

HCID 18399724HCID 18399724, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.5 g of 1-benzyl-4-bromo-1H-pyrrolo[3,2-c]pyridine in 25 ml of anhydrous ethanol and 8 g of piperazine are stirred at 120° C. for 15 hours under an inert atmosphere, then brought to ambient temperature and concentrated under reduced pressure. The residue is taken up in 200 ml of dichloromethane and washed with water. The organic phase is treated in conventional manner and then concentrated, enabling the expected product to be isolated.

Workup

  1. custombrought to ambient temperature
  2. concentrationconcentrated under reduced pressure
  3. washwashed with water
  4. additionThe organic phase is treated in conventional manner
  5. concentrationconcentrated
  6. customto be isolated

Sources & evidence

ORD record
ord-ab18189ee325450aa7c272b81bb0f822
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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