反应详情

A solution of 4.5 g of 1-benzyl-4-bromo-1H-pyrrolo[3,2-c]pyridine in 25 ml of anhydrous ethanol and 8 g of piperazine are stirred at 120° C. for 15 hours under an inert atmosphere, then brought to ambient temperature and concentrated under reduced pressure. The residue is taken up in 200 ml of dichloromethane and washed with water. The organic phase is treated in conventional manner and then concentrated, enabling the expected product to be isolated.

1. custombrought to ambient temperature
2. concentrationconcentrated under reduced pressure
3. washwashed with water
4. additionThe organic phase is treated in conventional manner
5. concentrationconcentrated
6. customto be isolated