Hydrochloric Acid → HCID 18399743, compound

HRID 1019002Notes

Reaction equation

HRID 1019002 reaction equation
Cl.[CH2:2]([N:9]1[C:17]2[CH:16]=[CH:15][N:14]=[C:13]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[C:12]=2[CH:11]=[CH:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[CH2:2]([N:9]1[C:17]2[CH:16]=[CH:15][N:14]=[C:13]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[CH:11]=[CH:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18399713HCID 18399713, compound

Product 1

HCID 18399743HCID 18399743, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15 ml of a 2.9N ethanolic HCl solution are added to a solution of 0.9 g of the compound obtained in Step 3 in 15 ml of ethanol. The reaction mixture is stirred for 24 hours at ambient temperature and then concentrated in vacuo, enabling the expected product to be isolated in dihydrochloride form. The dihydrochloride is converted into a free base by extraction in dichloromethane in the presence of water that has previously been adjusted to a basic pH by 20% sodium hydroxide solution.

Workup

  1. concentrationconcentrated in vacuo
  2. customto be isolated in dihydrochloride form
  3. extractionThe dihydrochloride is converted into a free base by extraction in dichloromethane in the presence of water that

Sources & evidence

ORD record
ord-43e9d38f796d4c9e8fe52814dc80d25e
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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