Hydrochloric Acid → HCID 18399739, compound

HRID 1019004Notes

Reaction equation

HRID 1019004 reaction equation
[O:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]4[C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[N:20](C(C5C=CC=CC=5)=C)[C:19]4=[O:35])[CH2:12][CH2:11]3)[C:4]=2[CH:3]=[CH:2]1.Cl>O>[O:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][N:18]4[C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[NH:20][C:19]4=[O:35])[CH2:14][CH2:15]3)[C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18399733HCID 18399733, compound

Product 1

HCID 18399739HCID 18399739, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

A mixture formed from 1.7 g of the product obtained in Step A of this Example, 5 ml of concentrated hydrochloric acid and 20 ml of water is heated at 65° C. for 30 minutes. After cooling, the reaction mixture is washed with ether, rendered basic to pH 9-10 by the addition of potassium carbonate and then extracted with ether. The expected product is obtained by drying and purification by chromatography on silica gel.

Workup

  1. temperatureAfter cooling
  2. washthe reaction mixture is washed with ether
  3. additionrendered basic to pH 9-10 by the addition of potassium carbonate
  4. extractionextracted with ether

Sources & evidence

ORD record
ord-f86774a77a884989822804063694d572
Source dataset
uspto-grants-2002_11
Patent number
US06486171B2

Reaction notes

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