反应详情

A solution of 11.5 g of triphenylphosphine in 60 ml of dichloromethane is added to a solution, cooled to 0° C., of 4 g of the compound obtained in Step 1 and 7.5 g of carbon tetrabromide in 100 ml of dichloromethane. After stirring for 48 hours at ambient temperature, the reaction mixture is concentrated in vacuo. The residue obtained is chromatographed on silica gel (dichloromethane/cyclohexane: 80/20), enabling the expected product to be isolated.

1. concentrationthe reaction mixture is concentrated in vacuo
2. customThe residue obtained
3. customis chromatographed on silica gel (dichloromethane/cyclohexane: 80/20)
4. customto be isolated