HCID 178418361, compound → HCID 178422324, compound

HRID 1019094Notes

Reaction equation

HRID 1019094 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[NH:10][C:11]2[C:17]([CH3:18])=[C:16]([N+:19]([O-])=O)[C:15]([CH3:22])=[CH:14][C:12]=2[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>C(O)C>[NH2:19][C:16]1[C:15]([CH3:22])=[CH:14][C:12]2[N:13]=[C:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[NH:10][C:11]=2[C:17]=1[CH3:18]

Participants

4

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178422325HCID 178422325, compound

Product 1

HCID 178422324HCID 178422324, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 2-(t-butoxycarbonyl)amino-4,6-dimethyl-5-nitrobenzimidazole (0.625 g, 2.04 mmol) in ethanol (70 mL) is treated with hydrogen at 45 psi for 15 hours. The mixture is filtered on Celite and the filtrate is rotary evaporated to afford 5-amino-2-(t-butoxycarbonyl)amino-4,6-dimethylbenzimidazole (0.5 g).

Workup

  1. filtrationThe mixture is filtered on Celite
  2. customthe filtrate is rotary evaporated

Sources & evidence

ORD record
ord-5654dc69af4240b5a05e8b427f4a4980
Source dataset
uspto-grants-2002_11
Patent number
US06486190B1

Reaction notes

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