5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1019106Notes

Reaction equation

HRID 1019106 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

Participants

3

Reactant 1

HCID 2365665-Fluoroisatin

Product 1

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Reagents, catalysts & solvents 1

HCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried under vacuum oven afford the title compound.

Workup

  1. temperaturerefluxed for 1.0 hr
  2. customThe reaction mixtures
  3. filtrationThe precipitate was then filtered
  4. washwashed with water
  5. customdried under vacuum oven

Sources & evidence

ORD record
ord-a49bcbd659af412b89f1f7c82c9f47c0
Source dataset
uspto-grants-2002_11
Patent number
US06486185B1

Reaction notes

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