反应详情

To a solution of benzotriazole (3 g) in DMF (38 mL) at r.t. was added a solution of 10N NaOH (2.75 mL). After stirring for 25 min., 3-trifluoromethylbenzyl bromide (4.39 mL) was added. The mixture was further stirred for 30 min., diluted with H2O, and extracted with EtOAc. The EtOAc extract was washed brine (2×), water, brine, dried (MgSO4) and concentrated. The residue was stirred in diethyl ether/hexane to afford 3.96 g of the title compound as a white solid.

1. stirringThe mixture was further stirred for 30 min.
2. extractionextracted with EtOAc
3. extractionThe EtOAc extract
4. washwas washed brine (2×), water, brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. stirringThe residue was stirred in diethyl ether/hexane