反应详情

To a flask containing ZnCl2 (0.57 g) at 0° C. was added dropwise propionyl chloride (32.0 g) followed by isobutyraldehyde (25.0 g) over 30 min. After a period of 2 h at room temperature, saturated NaHCO3 solution was added to the reaction mixture. The mixture was then extracted with EtOAc, dried over NaSO4, filtered and evaporated under reduced pressure. The title compound was distilled using a water pump aspirator

1. extractionThe mixture was then extracted with EtOAc
2. dry with materialdried over NaSO4
3. filtrationfiltered
4. customevaporated under reduced pressure
5. distillationThe title compound was distilled