HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triphenylarsine | HCID 11773 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 3-iodo-4-(4-(methylthio)phenyl)-2-(5H)-furanone | HCID 12150590 | — |
| Catalyst | Bis(benzonitrile)palladium chloride | HCID 498840 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl- | HCID 11044235 | — |
Reaction Steps
A mixture of 4 g of the product of Step 3, 3.7 g of PhB(OH)2, 0.4 g of Ph3As, 0.4 g of PdCl2(PhCN)2 in 100 ml of benzene and 15 ml of 2N NaOH is refluxed for 6 h. Ether(200 ml) is then added and the mixture is washed with 100 ml of saturated NaHCO3. The organic layer is dried over MgSO4 and concentrated. The residue is purified by flash chromatography on silica gel eluted with 4:1 hexane/EtOAc to give the tide compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486194B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-f54cca4d6bba48b5b1bed8a4c7162755 |
| Source note | uspto-grants-2002_11 |