反应详情

A mixture of 4 g of the product of Step 3, 3.7 g of PhB(OH)2, 0.4 g of Ph3As, 0.4 g of PdCl2(PhCN)2 in 100 ml of benzene and 15 ml of 2N NaOH is refluxed for 6 h. Ether(200 ml) is then added and the mixture is washed with 100 ml of saturated NaHCO3. The organic layer is dried over MgSO4 and concentrated. The residue is purified by flash chromatography on silica gel eluted with 4:1 hexane/EtOAc to give the tide compound.

1. temperatureis refluxed for 6 h
2. washthe mixture is washed with 100 ml of saturated NaHCO3
3. dry with materialThe organic layer is dried over MgSO4
4. concentrationconcentrated
5. customThe residue is purified by flash chromatography on silica gel
6. washeluted with 4:1 hexane/EtOAc
7. customto give the tide compound