Aluminium lithium hydride → HCID 15513019, compound

HRID 1019241Notes

Reaction equation

HRID 1019241 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH3:7][C:8]12[CH2:17][CH2:16][C@@H:15]([C:18]3([CH3:21])[O:20][CH2:19]3)[CH2:14][C:13]1=[C:12]([CH2:22][CH2:23][CH3:24])[C:11](=[O:25])[CH2:10][CH2:9]2>CCOCC>[CH3:7][C:8]12[CH2:17][CH2:16][C@@H:15]([C:18]([OH:20])([CH3:19])[CH3:21])[CH2:14][C:13]1=[C:12]([CH2:22][CH2:23][CH3:24])[CH:11]([OH:25])[CH2:10][CH2:9]2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 131723658HCID 131723658, compound

Product 1

HCID 15513019HCID 15513019, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a suspension of 0.69 g (18.3 mmol) of LiAlH4 in 150 mL of anhydrous ether cooled with ice bath was added a solution of the compound obtained from step B in anhydrous ether. The reaction mixture was stirred for 30 min. with cooling, 3 hours at room temperature, then quenched with water saturated ether and 2 mL of 10% NaOH solution. After filtration, the solvent was removed by evaporation to give title product.

Workup

  1. temperaturecooled with ice bath
  2. customquenched with water saturated ether and 2 mL of 10% NaOH solution
  3. filtrationAfter filtration
  4. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-e7f909ebbb984af088d6754f518c0e9c
Source dataset
uspto-grants-2002_11
Patent number
US06486201B1

Reaction notes

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