HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1019347Generated: October 27, 2026
Cyclopropyl methyl ketone → 1-Cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)-1,3-propanedione
https://huagongshe.com/reaction/1019347
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropyl methyl ketone | HCID 13004 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Methyl 2-(methylthio)-4-(trifluoromethyl)benzoate | HCID 10944828 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-Cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)-1,3-propanedione | HCID 11120178 | 94.7% |
Reaction Steps
Sodium methoxide (0.54 g, 0.01M) was added to a mixture of methyl 2-methylthio-4-trifluoromethylbenzoate (1.25 g. 0.005M) and cyclopropyl methyl ketone (0.5 g, 0,006M) in anhydrous N-methylpyrrolidinone and heated at 30° C. for 3 hours. The cooled mixture was acidified, extracted (ether), washed (Water) and evaporated to give 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)propane-1,3-dione (1.43 g), m.p.68° C. in a yield of 94%. The purity of the product was greater than 95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06486356B2 |
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| Source dataset | uspto-grants-2002_11 |
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| ORD ID | ord-d01d62b3eda746129c12e8a6784c4e89 |
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| Source note | uspto-grants-2002_11 |
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