反应详情

温度

30 °C

Sodium methoxide (0.54 g, 0.01M) was added to a mixture of methyl 2-methylthio-4-trifluoromethylbenzoate (1.25 g. 0.005M) and cyclopropyl methyl ketone (0.5 g, 0,006M) in anhydrous N-methylpyrrolidinone and heated at 30° C. for 3 hours. The cooled mixture was acidified, extracted (ether), washed (Water) and evaporated to give 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)propane-1,3-dione (1.43 g), m.p.68° C. in a yield of 94%. The purity of the product was greater than 95%.

1. extractionextracted (ether)
2. washwashed (Water)
3. customevaporated