Hydrochloric Acid → HCID 18398956, compound

HRID 1019378Notes

Reaction equation

HRID 1019378 reaction equation
C(OC([NH:8][NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([N:18]2[C:27]([C:28]([O:30][CH3:31])=[O:29])=[C:26]([C:32]3[CH:37]=[C:36]([O:38][CH3:39])[C:35]([O:40][CH3:41])=[C:34]([O:42][CH3:43])[CH:33]=3)[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]2=[O:44])=[CH:14][CH:13]=1)=[O:11])=O)(C)(C)C.[ClH:45]>O1CCOCC1>[ClH:45].[CH3:31][O:30][C:28]([C:27]1[N:18]([C:15]2[CH:14]=[CH:13][C:12]([C:10]([NH:9][NH2:8])=[O:11])=[CH:17][CH:16]=2)[C:19](=[O:44])[C:20]2[C:25]([C:26]=1[C:32]1[CH:33]=[C:34]([O:42][CH3:43])[C:35]([O:40][CH3:41])=[C:36]([O:38][CH3:39])[CH:37]=1)=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 54430975HCID 54430975, compound

Product 1

HCID 18398956HCID 18398956, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent3×

Procedure

The compound obtained in Example 23 is dissolved in dioxane (2 ml), and thereto is added a 4M solution of hydrogen chloride in dioxane (5 ml), and the mixture is stirred at room temperature. To the reaction mixture is further added a 4M solution of hydrogen chloride in dioxane (5 ml), and the mixture is stirred for three hours. The reaction mixture is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (solvent; chloroform:methanol=30:1) to give 3-methoxycarbonyl-2-[4-(hydrazinocarbonyl)phenyl]-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone hydrochloride as listed in Table 4.

Workup

  1. stirringthe mixture is stirred for three hours
  2. concentrationThe reaction mixture is concentrated under reduced pressure
  3. customthe residue is purified by silica gel column chromatography (solvent; chloroform:methanol=30:1)

Sources & evidence

ORD record
ord-9a365ad1994947278d255050f23f3b8c
Source dataset
uspto-grants-2002_11
Patent number
US06486155B1

Reaction notes

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