Hydrochloric Acid → HCID 18399304, compound

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Reaction Steps

To the compound obtained in Example 67 (200 mg) is added a 4M solution of hydrogen chloride in ethyl acetate (10 ml) and the mixture is allowed to stand at room temperature for one hour. The reaction mixture is concentrated under reduced pressure, and to the residue is added ethyl acetate. The mixture is washed with a saturated aqueous sodium hydrogen carbonate solution, dried, and concentrated under reduced pressure to give 2-amino-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (146 mg) as listed in Table 6.

Provenance & Evidence