Hydrochloric Acid → HCID 18399304, compound

HRID 1019380Notes

Reaction equation

HRID 1019380 reaction equation
C(OC([NH:8][N:9]1[C:18]([C:19]([O:21][CH3:22])=[O:20])=[C:17]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]1=[O:35])=O)(C)(C)C.Cl>C(OCC)(=O)C>[NH2:8][N:9]1[C:18]([C:19]([O:21][CH3:22])=[O:20])=[C:17]([C:23]2[CH:24]=[C:25]([O:33][CH3:34])[C:26]([O:31][CH3:32])=[C:27]([O:29][CH3:30])[CH:28]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]1=[O:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18399126HCID 18399126, compound

Product 1

HCID 18399304HCID 18399304, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To the compound obtained in Example 67 (200 mg) is added a 4M solution of hydrogen chloride in ethyl acetate (10 ml) and the mixture is allowed to stand at room temperature for one hour. The reaction mixture is concentrated under reduced pressure, and to the residue is added ethyl acetate. The mixture is washed with a saturated aqueous sodium hydrogen carbonate solution, dried, and concentrated under reduced pressure to give 2-amino-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (146 mg) as listed in Table 6.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionto the residue is added ethyl acetate
  3. washThe mixture is washed with a saturated aqueous sodium hydrogen carbonate solution
  4. customdried
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-96496bf36a2b4d339ba0e7feb493bb06
Source dataset
uspto-grants-2002_11
Patent number
US06486155B1

Reaction notes

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