Sodium Hydroxide → HCID 11049049, compound

HRID 1019401Notes

Reaction equation

HRID 1019401 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18]([C:19]([O:21][CH3:22])=[O:20])=[C:17]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[C:16]3[C:11](=[CH:12][C:13]([OH:35])=[CH:14][CH:15]=3)[C:10]2=[O:36])=[CH:5][CH:4]=1.[OH-].[Na+]>C(Cl)(Cl)Cl>[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18]([C:19]([O:21][CH3:22])=[O:20])=[C:17]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[C:16]3[C:11](=[CH:12][C:13]([OH:35])=[CH:14][CH:15]=3)[C:10]2=[O:36])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18399385HCID 18399385, compound

Product 1

HCID 11049049HCID 11049049, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A suspension of the compound obtained in Example 224 in chloroform is neutralized with a 2M aqueous sodium hydroxide solution under ice-cooling, and the mixture is extracted with ethyl acetate. The extract is washed, dried, and concentrated under reduced pressure. The residue is dissolved in a small amount of ethyl acetate, and the mixture is crystallized from diethyl ether to give 2-(4-aminophenyl)-7-hydroxy-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 38.

Workup

  1. temperaturecooling
  2. extractionthe mixture is extracted with ethyl acetate
  3. washThe extract is washed
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. dissolutionThe residue is dissolved in a small amount of ethyl acetate
  7. customthe mixture is crystallized from diethyl ether

Sources & evidence

ORD record
ord-0c1ec3466c9f4f88a3be00ea5b81d427
Source dataset
uspto-grants-2002_11
Patent number
US06486155B1

Reaction notes

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