Sodium Hydroxide → HCID 11049049, compound

Participants

Reaction Steps

A suspension of the compound obtained in Example 224 in chloroform is neutralized with a 2M aqueous sodium hydroxide solution under ice-cooling, and the mixture is extracted with ethyl acetate. The extract is washed, dried, and concentrated under reduced pressure. The residue is dissolved in a small amount of ethyl acetate, and the mixture is crystallized from diethyl ether to give 2-(4-aminophenyl)-7-hydroxy-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 38.

Provenance & Evidence