Sulfamide → HCID 11379214, compound

HRID 1019500Notes

Reaction equation

HRID 1019500 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH2:11].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH:11][S:12]([NH2:15])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 82267SulfamideHCID 573560261-(2H-1,3-Benzodioxol-2-yl)methanamine

Product 1

HCID 11379214HCID 11379214, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

C-Benzo[1,3]dioxol-2-yl-methylamine (2.94 g, 19.4 mmol) and sulfamide (3.74 g, 38.9 mmol) were combined in dry dioxane (50 mL) and the solution was heated to reflux overnight. The reaction was concentrated and the residue was chromatographed (2% to 10% acetone in dichloromethane) to yield the title compound as a white solid.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. customthe residue was chromatographed (2% to 10% acetone in dichloromethane)

Sources & evidence

ORD record
ord-e822745d3c444adaadfe5ca915f92a56
Source dataset
uspto-grants-2014_05
Patent number
US08716231B2

Reaction notes

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