HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 2-bromo-4,5,7,8-tetrahydro-6H-thieno[2,3-d]azepine-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4,5,7,8-Tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester | HCID 59302541 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Ethyl 2-bromo-4,5,7,8-tetrahydro-6H-thieno[2,3-d]azepine-6-carboxylate | HCID 57354995 | 98.6% |
Reaction Steps
The product of Example 1, step (d) (80 mg, 0.35 mmol) was dissolved in 2 mL of 1:1 CHCl3:HOAc and treated with NBS (62 mg, 0.35 mmol). After 15 minutes, the reaction was concentrated to dryness, dissolved in a minimal amount of EtOAc and filtered through a pad of silica gel. The filtrate was evaporated to give 105 mg of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716276B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-19f447c7c9474980ba711fa53918f5c7 |
| Source note | uspto-grants-2014_05 |