HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester | HCID 86687938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt | HCID 89620421 | — |
Reaction Steps
1.1 mL 1M aqueous lithiumhydroxide solution was added to 300 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester in 10 mL dioxane. The reaction was stirred 2 h at RT and evaporated to give 270 mg desired product. Rt: 1.09 min (method A), (M+H)+: 315
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716277B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-19e510898c9c4a2e95f9730676dd696a |
| Source note | uspto-grants-2014_05 |