Lithium Hydroxide → (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt

HRID 1019639Notes

Reaction equation

HRID 1019639 reaction equation
[OH-].[Li+:2].C([O:5][C:6](=[O:27])[CH2:7][C:8]1[N:9]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[N:12]=1)C>O1CCOCC1>[Li+:2].[F:26][C:23]1[CH:22]=[CH:21][C:20]([N:9]2[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:12]=[C:8]2[CH2:7][C:6]([O-:27])=[O:5])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86687938(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester

Product 1

HCID 89620421(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.1 mL 1M aqueous lithiumhydroxide solution was added to 300 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester in 10 mL dioxane. The reaction was stirred 2 h at RT and evaporated to give 270 mg desired product. Rt: 1.09 min (method A), (M+H)+: 315

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-19e510898c9c4a2e95f9730676dd696a
Source dataset
uspto-grants-2014_05
Patent number
US08716277B2

Reaction notes

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