HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[5'-(4-Fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 2-(5'-Bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)ethanol | HCID 66660771 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[5'-(4-Fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethanol | HCID 66660852 | — |
Reaction Steps
Under an inert atmosphere, 3.60 g (12.62 mmol) of 2-(5′-bromo-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)ethanol, prepared in step 1.1., 3.53 g (25.25 mmol) of 4-fluorophenylboronic acid, 5.23 g (37.87 mmol) of potassium carbonate and 4.88 g (15.15 mmol) of tetrabutylammonium bromide in suspension are introduced into 20 mL of water. 0.142 g (0.63 mmol) of Pd(OAc)2 is then added. The reaction mixture is refluxed for 24 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716289B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-2dbbc6d0195d4881aab5b49a9e7324a7 |
| Source note | uspto-grants-2014_05 |