反应详情

Under an inert atmosphere, 3.60 g (12.62 mmol) of 2-(5′-bromo-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)ethanol, prepared in step 1.1., 3.53 g (25.25 mmol) of 4-fluorophenylboronic acid, 5.23 g (37.87 mmol) of potassium carbonate and 4.88 g (15.15 mmol) of tetrabutylammonium bromide in suspension are introduced into 20 mL of water. 0.142 g (0.63 mmol) of Pd(OAc)2 is then added. The reaction mixture is refluxed for 24 hours.

1. temperatureThe reaction mixture is refluxed for 24 hours