Dimethylamine → HCID 66661113, compound

HRID 1019696Notes

Reaction equation

HRID 1019696 reaction equation
[C:1]([CH:3]=[C:4]1[CH2:7][N:6]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:5]1)#[N:2].[CH3:15][NH:16][CH3:17]>CO>[C:1]([CH2:3][C:4]1([N:16]([CH3:17])[CH3:15])[CH2:7][N:6]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:5]1)#[N:2]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 457892161-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine

Product 1

HCID 66661113HCID 66661113, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
80 °C

Procedure

1.20 g (6,18 mmol) of tert-butyl 3-cyanomethyleneazetidine-1-carboxylate (WO 2009/064 835) are dissolved in 15 mL of methanol in a sealed tube. 6.18 mL (12.36 mmol) of a solution of dimethylamine in methanol are added and the reaction medium is stirred at 80° C. for 3 hours.

Sources & evidence

ORD record
ord-a7755cafe4bd4b9796f51dfcf5647c0e
Source dataset
uspto-grants-2014_05
Patent number
US08716289B2

Reaction notes

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