Diisopropylethylamine → HCID 86661347, compound

HRID 1019701Notes

Reaction equation

HRID 1019701 reaction equation
Cl.[CH3:2][C:3]1([CH2:9][CH2:10][NH:11][C:12](=[O:24])[O:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([C:20](=[O:23])[NH:21][CH3:22])[CH:16]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl[C:26]1[N:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][N:27]=1.C(N(CC)C(C)C)(C)C>C(#N)C>[CH3:2][C:3]1([CH2:9][CH2:10][NH:11][C:12](=[O:24])[O:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([C:20](=[O:23])[NH:21][CH3:22])[CH:16]=2)[CH2:4][CH2:5][N:6]([C:26]2[N:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][N:27]=2)[CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 86661345HCID 86661345, compound

Product 1

HCID 86661347HCID 86661347, compoundYield 74.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The process is performed according to the procedure described in Example 12 (step 12.5.). Starting with 0.30 g (0.83 mmol) of 3-methylcarbamoylisoxazol-5-ylmethyl [2-(4-methylpiperidin-4-yl)ethyl]carbamate hydrochloride, 0.23 g (1.25 mmol) of 2-chloro-4-trifluoromethylpyrimidine and 430 μL (2.49 mmol) of N,N-diisopropylethylamine, dissolved in 2.77 mL of acetonitrile, 0.29 g of expected product is obtained in the form of a powder.

Sources & evidence

ORD record
ord-7a516c78f2c04dc6aa3fd8d433616f38
Source dataset
uspto-grants-2014_05
Patent number
US08716289B2

Reaction notes

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