Hydrochloric Acid → HCID 66660885, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 11 (step 11.2.). Starting with 3.67 g (10.60 mmol) of tert-butyl {2-[1- (4-trifluoromethylpyrimidin-2-yl)azetidin-3-yl]ethyl}carbamate and 10.60 mL (42.38 mmol) of a 4N solution of hydrogen chloride in dioxane, 1.75 g of product are obtained in the form of a yellow oil, after purification by chromatography on silica gel, eluting with a 100/0/0 to 90/10/1 mixture of dichloromethane, methanol and 28% aqueous ammonia.

Provenance & Evidence