Hydrochloric Acid → HCID 66660885, compound

HRID 1019710Notes

Reaction equation

HRID 1019710 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[CH2:12][CH:11]([CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C)[CH2:10]2)[N:4]=1.Cl>O1CCOCC1>[F:23][C:2]([F:1])([F:24])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[CH2:12][CH:11]([CH2:13][CH2:14][NH2:15])[CH2:10]2)[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86661352HCID 86661352, compound

Product 1

HCID 66660885HCID 66660885, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The process is performed according to the procedure described in Example 11 (step 11.2.). Starting with 3.67 g (10.60 mmol) of tert-butyl {2-[1- (4-trifluoromethylpyrimidin-2-yl)azetidin-3-yl]ethyl}carbamate and 10.60 mL (42.38 mmol) of a 4N solution of hydrogen chloride in dioxane, 1.75 g of product are obtained in the form of a yellow oil, after purification by chromatography on silica gel, eluting with a 100/0/0 to 90/10/1 mixture of dichloromethane, methanol and 28% aqueous ammonia.

Workup

  1. customare obtained in the form of a yellow oil
  2. customafter purification by chromatography on silica gel
  3. washeluting with a 100/0/0 to 90/10/1 mixture of dichloromethane, methanol and 28% aqueous ammonia

Sources & evidence

ORD record
ord-9b6b452b45f5471788ebd230ead1eea1
Source dataset
uspto-grants-2014_05
Patent number
US08716289B2

Reaction notes

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