Sodium methanethiolate → HCID 178446220, compound

HRID 1019720Notes

Reaction equation

HRID 1019720 reaction equation
Br[C:2]1[N:7]=[C:6]2[N:8]([CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:9]([OH:11])=[N:10][C:5]2=[N:4][CH:3]=1.[CH3:17][S-:18].[Na+]>CN1CCCC1=O>[CH3:17][S:18][C:2]1[N:7]=[C:6]2[N:8]([CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:9]([OH:11])=[N:10][C:5]2=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 178446210HCID 178446210, compound

Product 1

HCID 178446220HCID 178446220, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound was prepared by reacting 6-bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol (1.0 equiv), sodium thiomethoxide (1.4 equiv), and N-methylpyrrolidone (5.9 volume equivalents) in a manner analagous to Example 1(c). LCMS m/z (APCI)=253.0 (M+H).

Sources & evidence

ORD record
ord-f37120b4eb6f4dae898c890c1eecfe10
Source dataset
uspto-grants-2014_05
Patent number
US08716291B2

Reaction notes

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