3-Pentanamine → HCID 57880837, compound

HRID 1019722Notes

Reaction equation

HRID 1019722 reaction equation
Cl[C:2]1[C:3]([NH2:12])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH2:13][CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16]>>[CH3:16][CH2:15][CH:14]([NH:13][C:2]1[C:3]([NH2:12])=[N:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:11]=1)[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 120193-PentanamineHCID 8172743-Chloroquinoxalin-2-amine

Product 1

HCID 57880837HCID 57880837, compoundYield 78%

Conditions

Temperature
120 °C

Procedure

A thick-walled microwave bottle equipped with a stirbar was charged with 3-chloroquinoxalin-2-amine (1.0 equiv) and 20 volume equivalents of 3-aminopentane. The bottle was fitted with a septum and cap and heated to 120° C. in a microwave for 30 min. The resulting solution was concentrated in vacuo. Flash chromatography (20%-60% EtOAc/Hexanes) provided the title compound (78%) as a yellow solid. LCMS m/z (APCI)=231.1 (M+H).

Workup

  1. customA thick-walled microwave bottle equipped with a stirbar
  2. customThe bottle was fitted with a septum
  3. customcap
  4. concentrationThe resulting solution was concentrated in vacuo

Sources & evidence

ORD record
ord-1e61282e350a48feaf37d6470e9eb49d
Source dataset
uspto-grants-2014_05
Patent number
US08716291B2

Reaction notes

Loading…