Hydrochloric Acid → HCID 67467892, compound

HRID 1019761Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:26]=[C:25]([NH:27][C:28]([NH:30][C:31]2[CH:36]=[N:35][C:34]([C:37]#[N:38])=[CH:33][N:32]=2)=[O:29])[C:24]([O:39][CH3:40])=[CH:23][C:4]=1[CH2:5][CH2:6][N:7]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)C(=O)OC(C)(C)C>O1CCOCC1.C(Cl)Cl>[ClH:2].[Cl:2][C:3]1[C:4]([CH2:5][CH2:6][NH:7][CH2:15][C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)=[CH:23][C:24]([O:39][CH3:40])=[C:25]([NH:27][C:28]([NH:30][C:31]2[CH:36]=[N:35][C:34]([C:37]#[N:38])=[CH:33][N:32]=2)=[O:29])[CH:26]=1

Participants

Conditions

Temperature: 10 °C

Procedure

A solution of HCl in 1,4-dioxane (0.05 mL) was added to a solution of tert-butyl 2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenethyl(4-fluorobenzyl)-carbamate (0.03 g, 0.4 mmol) in DCM (5 mL) at 0° C. The solution was allowed to warm to 10° C. and stirred at this temperature for one hour. The solvents were removed under reduced pressure and the residue was washed with methanol (2×5 mL) to give the title compound (0.017 g, 68%) as a white solid.

Workup

customThe solvents were removed under reduced pressure
washthe residue was washed with methanol (2×5 mL)

Sources & evidence

ORD record: ord-2a1dde93ea1849219ef425810d079306
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08716287B2

Reaction notes

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