5-(Boc-amino)-1-pentanol → tert-Butyl 5-(4-chloro-5-fluoro-2-(hydroxymethyl)phenoxy)pentylcarbamate

HRID 1019832Notes

Reaction equation

HRID 1019832 reaction equation
[Cl:1][C:2]1[C:3]([F:13])=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([O:9]C)=O.O[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24]>>[Cl:1][C:2]1[C:3]([F:13])=[CH:4][C:5]([O:12][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[C:6]([CH2:7][OH:9])[CH:11]=1

Participants

3

Reactant 2

HCID 44561365-(Boc-amino)-1-pentanolHCID 67449737Methyl 5-chloro-4-fluoro-2-hydroxybenzoate

Product 1

HCID 68229609tert-Butyl 5-(4-chloro-5-fluoro-2-(hydroxymethyl)phenoxy)pentylcarbamate

Procedure

Intermediate I-30 was prepared from methyl 5-chloro-4-fluoro-2-hydroxybenzoate and tert-butyl 5-hydroxypentylcarbamate analogously to Examples 27-28.

Sources & evidence

ORD record
ord-3814e105d7234f539558d33a2ba852c8
Source dataset
uspto-grants-2014_05
Patent number
US08716293B2

Reaction notes

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