Benzoic acid, 5-chloro-2-hydroxy-, methyl ester → tert-Butyl 5-(4-chloro-2-(hydroxymethyl)phenoxy)pentylcarbamate

HRID 1019833Notes

Reaction equation

HRID 1019833 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([O:9]C)=O.O[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[C:6]([CH2:7][OH:9])[CH:11]=1

Participants

3

Reactant 2

HCID 77684Benzoic acid, 5-chloro-2-hydroxy-, methyl esterHCID 44561365-(Boc-amino)-1-pentanol

Product 1

HCID 68229693tert-Butyl 5-(4-chloro-2-(hydroxymethyl)phenoxy)pentylcarbamate

Procedure

Intermediate I-31 was prepared from methyl 5-chloro-2-hydroxybenzoate and tert-butyl 5-hydroxypentylcarbamate analogously to Examples 24-26.

Sources & evidence

ORD record
ord-c327f163f30d4b3fa120a91a9cb8abd3
Source dataset
uspto-grants-2014_05
Patent number
US08716293B2

Reaction notes

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