Thiourea → HCID 131731372, compound

HRID 1019838Notes

Reaction equation

HRID 1019838 reaction equation
[C:1]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][Br:12])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[NH2:13][C:14]([NH2:16])=[S:15]>C(O)C>[BrH:12].[C:1]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][S:15][C:14](=[NH:13])[NH2:16])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 21111669HCID 21111669, compound

Product 1

HCID 131731372HCID 131731372, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Bromobutyl pivalate (0.71 mol) and thiourea (0.78 mol) were dissolved in ethanol (330 ml) and the resulting mixture was refluxed for 1 h. The solvent was removed under vacuum. The resulting residue was used in the next step without further purification. Yield: 210 g (95% yield).

Workup

  1. temperaturethe resulting mixture was refluxed for 1 h
  2. customThe solvent was removed under vacuum
  3. customThe resulting residue was used in the next step without further purification

Sources & evidence

ORD record
ord-c3fa1d267e3c49918c0604b06e3de9a5
Source dataset
uspto-grants-2014_05
Patent number
US08716293B2

Reaction notes

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