3-Bromo-1-propanol → C-{1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-piperidin-4-yl}-methylamine

HRID 1019870Notes

Reaction equation

HRID 1019870 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:15][CH2:16][CH2:17][OH:18].C(OC(=O)[NH:25][CH2:26][CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)(C)(C)C>>[CH3:13][O:12][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:18][CH2:17][CH2:16][CH2:15][N:30]3[CH2:31][CH2:32][CH:27]([CH2:26][NH2:25])[CH2:28][CH2:29]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 123083-Bromo-1-propanolHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamateHCID 126864152-Chloro-7-methoxyquinoxaline

Product 1

HCID 66746562C-{1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-piperidin-4-yl}-methylamine

Procedure

The title compound is prepared as a brown viscous oil following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 3-bromo-propan-1-ol and piperidin-4-ylmethyl-carbamic acid tert-butyl ester as starting materials.

Sources & evidence

ORD record
ord-e5306eb2050442c7a3928a21ea6d2237
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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