2-Bromoethanol → HCID 66747362, compound

HRID 1019889Notes

Reaction equation

HRID 1019889 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:15][CH2:16][OH:17].C(O[C:23](=[O:29])[NH:24][CH:25]1[CH2:28][NH:27][CH2:26]1)(C)(C)C.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38](C(O)=O)[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[CH3:13][O:12][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:17][CH2:16][CH2:15][N:27]3[CH2:26][CH:25]([NH:24][C:23]([C:38]4[CH:39]=[CH:40][C:34]5[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=5[CH:37]=4)=[O:29])[CH2:28]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 108982-BromoethanolHCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 15194053-Aminoazetidine, 3-BOC protectedHCID 126864152-Chloro-7-methoxyquinoxaline

Product 1

HCID 66747362HCID 66747362, compound

Procedure

The title compound is prepared as an off-white lyophilizated powder following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, 2-bromo-ethanol, azetidin-3-yl-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-e587d342914f47919cf2e5980885fe44
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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