反应详情

To a solution of compound 3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester (3 g) in 20 mL of methanol was added 10% palladium hydroxide (300 mg) under an atmosphere of nitrogen and the mixture was stirred at room temperature under an atmosphere of hydrogen for 4 hours. The reaction mixture was filtered through celite and the solvent was evaporated. Diethyl ether was added to the product, the mixture was stirred, filtered and the obtained solid was rewashed with diethyl ether and dried under vacuum to yield piperidine-3-carboxylic acid [6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amide (compound #16A) as a white solid (1.8 g).

1. filtrationThe reaction mixture was filtered through celite
2. customthe solvent was evaporated
3. additionDiethyl ether was added to the product
4. stirringthe mixture was stirred
5. filtrationfiltered
6. customdried under vacuum