反应详情

To a solution of (R)-3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester (XXX) (7.0 g) in 50 mL of methanol was added 10% palladium hydroxide (1.5 g) under an atmosphere of nitrogen and the mixture was stirred at room temperature under an atmosphere of hydrogen for 8 hours. The reaction mixture was filtered through celite and the solvent was evaporated. The obtained product was taken in diethyl ether, stirred, filtered, the residue was washed with diethyl ether and dried under vacuum to yield (R)-piperidine-3-carboxylic acid [6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amide (compound #18A) as a white solid (3.5 g, 72%), melting point 210-213° C.

1. filtrationThe reaction mixture was filtered through celite
2. customthe solvent was evaporated
3. stirringstirred
4. filtrationfiltered
5. washthe residue was washed with diethyl ether
6. customdried under vacuum