Hydrochloric Acid → 1-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-3-yl-urea hydrochloride

HRID 1020072Notes

Reaction equation

HRID 1020072 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])[N:22]=[CH:21][N:20]=2)=[O:17])[CH2:10]1)=O)(C)(C)C>ClCCl>[ClH:1].[CH3:32][O:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[C:23]1[N:22]=[CH:21][N:20]=[C:19]([NH:18][C:16]([NH:15][CH:11]2[CH2:12][CH2:13][CH2:14][NH:9][CH2:10]2)=[O:17])[CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 595091183-{3-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 671847031-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-3-yl-urea hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethereal HCl (2 ml) was added to a solution of 3-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester (XLII) (0.20 g, 0.47 mmol) in dry dichloromethane (2 ml) and the mixture was stirred for 2 hours at room temperature. The reaction was monitored by TLC. After completion, the solvent was removed from the reaction mixture to provide 0.20 g of 1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-3-yl-urea hydrochloride (compound #23A).

Workup

  1. customAfter completion, the solvent was removed from the reaction mixture

Sources & evidence

ORD record
ord-896b4cfd37554b95a47d776bedf11693
Source dataset
uspto-grants-2014_05
Patent number
US08716296B2

Reaction notes

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