Hydrochloric Acid → HCID 66599641, compound

HRID 1020090Notes

Reaction equation

HRID 1020090 reaction equation
[CH3:1][C:2]1([C:5]([O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH2:28][NH:29]C(OC(C)(C)C)=O)[C:15]([NH:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[CH:24]=[N:23][CH:22]=[CH:21]4)=[O:16])=[CH:10][CH:9]=2)=[O:6])[CH2:4][CH2:3]1.[ClH:37]>C(Cl)Cl>[ClH:37].[ClH:37].[CH3:1][C:2]1([C:5]([O:7][C:8]2[CH:9]=[CH:10][C:11]([CH:14]([CH2:28][NH2:29])[C:15]([NH:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[CH:24]=[N:23][CH:22]=[CH:21]4)=[O:16])=[CH:12][CH:13]=2)=[O:6])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59563732HCID 59563732, compound

Product 1

HCID 66599641HCID 66599641, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4-(3-(tert-butoxycarbonylamino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenyl 1-methylcyclopropanecarboxylate (E11) in CH2Cl2 was added HCl (4N in dioxane) and the solution was stirred for 8-10 h. The solvents were evaporated to give pure 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenyl 1-methylcyclopropanecarboxylate dihydrochloride (E12).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-cf9ffa5a7ca34299ace67c63db4c37f7
Source dataset
uspto-grants-2014_05
Patent number
US08716310B2

Reaction notes

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