huagongshe.com
HRID1020116

反应详情

EQUATION

反应方程式

HRID 1020116 的结构方程式

REACTANTS

反应物

2
结构：CO
HCID887

Methanol

CH4O

结构：CC(C)(C)[Si](C)(C)OCc1ccc(CC(=O)O)s1
HCID59563774

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)Cc1ccc(CO[Si](C)(C)C(C)(C)C)s1
HCID59563701

未命名化合物

PROCEDURE

实验过程

To 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetic acid (E231) in MeOH at 0° C. was added TMS-CH2N2 until the solution persisted in a yellow color and TLC indicated completion of the reaction. The solution stirred for 30 min and then was quenched with a few drops of AcOH. The solvents were evaporated and column chromatography (SiO2, 0-15% EtOAc/Hexanes) gave pure methyl 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetate (E232).

WORKUP

后处理

  1. customcompletion of the reaction
  2. customwas quenched with a few drops of AcOH
  3. customThe solvents were evaporated