HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(5-((Tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetic acid | HCID 59563774 | — |
| Product | Methyl 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetate | HCID 59563701 | — |
Reaction Steps
To 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetic acid (E231) in MeOH at 0° C. was added TMS-CH2N2 until the solution persisted in a yellow color and TLC indicated completion of the reaction. The solution stirred for 30 min and then was quenched with a few drops of AcOH. The solvents were evaporated and column chromatography (SiO2, 0-15% EtOAc/Hexanes) gave pure methyl 2-(5-((tert-butyldimethylsilyloxy)methyl)thiophen-2-yl)acetate (E232).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716310B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c1da7b84339e4b1bbaafe82b375b3af0 |
| Source note | uspto-grants-2014_05 |