Hydrochloric Acid → HCID 66599801, compound

HRID 1020122Notes

Reaction equation

HRID 1020122 reaction equation
C(OC([NH:8][CH2:9][CH:10]([C:24]1[CH:42]=[CH:41][C:27]([O:28][CH2:29][C:30]([O:32][C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:34]=2[CH3:40])=[O:31])=[CH:26][CH:25]=1)[C:11]([NH:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[N:19][CH:18]=[CH:17]2)=[O:12])=O)(C)(C)C.[ClH:43]>C(Cl)Cl>[ClH:43].[ClH:43].[NH2:8][CH2:9][CH:10]([C:24]1[CH:25]=[CH:26][C:27]([O:28][CH2:29][C:30]([O:32][C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:34]=2[CH3:40])=[O:31])=[CH:41][CH:42]=1)[C:11]([NH:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[N:19][CH:18]=[CH:17]2)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59563756HCID 59563756, compound

Product 1

HCID 66599801HCID 66599801, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2,4-dimethylphenyl 2-(4-(3-(tert-butoxycarbonylamino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenoxy)acetate (E252) in CH2Cl2 was added HCl (4 N, dioxane) and the solution was stirred overnight. The solvents were evaporated to give 2,4-dimethylphenyl 2-(4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenoxy)acetate dihydrochloride (E253).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-c934933c3ac1404ebd0bd62dc8d0e45c
Source dataset
uspto-grants-2014_05
Patent number
US08716310B2

Reaction notes

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