HCID 59563797, compound → HCID 59563721, compound

HRID 1020130Notes

Reaction equation

HRID 1020130 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH:11]([C:22]1[CH:27]=[CH:26][C:25]([O:28][Si:29]([CH:36]([CH3:38])[CH3:37])([CH:33]([CH3:35])[CH3:34])[CH:30]([CH3:32])[CH3:31])=[CH:24][CH:23]=1)[C:12]([O:14]CC1C=CC=CC=1)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CCOC(C)=O.[Pd]>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH:11]([C:22]1[CH:27]=[CH:26][C:25]([O:28][Si:29]([CH:30]([CH3:32])[CH3:31])([CH:33]([CH3:35])[CH3:34])[CH:36]([CH3:37])[CH3:38])=[CH:24][CH:23]=1)[C:12]([OH:14])=[O:13])=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

4

Reactant 1

HCID 59563797HCID 59563797, compound

Product 1

HCID 59563721HCID 59563721, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To benzyl 4-(tert-butoxycarbonylamino)-2-(4-(triisopropylsilyloxy)phenyl)butanoate (E304) in EtOAc was added Pd/C (10%) and the solution was kept under a H2 atmosphere for 2 h. The mixture was filtered over Celite and the solvent was evaporated to give 4-(tert-butoxycarbonylamino)-2-(4-(triisopropylsilyloxy)phenyl)butanoic acid (E305).

Workup

  1. filtrationThe mixture was filtered over Celite
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-0bc42808cd824793a7ddf29e4a2c3ce9
Source dataset
uspto-grants-2014_05
Patent number
US08716310B2

Reaction notes

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