4-Aminotetrahydropyran → HCID 52917265, compound

HRID 1020159Notes

Reaction equation

HRID 1020159 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[O:19]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]1>>[C:13]1([C:12]#[C:11][C:8]2[CH:7]=[N:6][C:5]([NH:25][CH:22]3[CH2:23][CH2:24][O:19][CH2:20][CH2:21]3)=[N:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 52917265HCID 52917265, compound

Procedure

The title compound, MS: m/e=280.3 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine(example 1, step 2) and tetrahydro-pyran-4-ylamine

Sources & evidence

ORD record
ord-27617d3eba8d48e6b54caa2453a818ff
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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