HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) → HCID 61427365, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) | HCID 73228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 61427365 | HCID 61427365 | — |
Reaction Steps
4-(chloromethyl)thiazol-2-amine hydrochloride (Intermediate I) (1 meq) was suspended in THF (20 ml) and DIEA (2 eq.) was added followed by addition of N-methyl-methoxyethylamine (1 eq.). The reaction was heated at reflux overnight. The reaction was concentrated by evaporation to solid residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716320B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c228023a2937487aa86ada3c152d0636 |
| Source note | uspto-grants-2014_05 |